In 2025 (I refer to the update performed on 29/10/2025), the Italian National Institute of Health (Istituto Superiore di Sanità, ISS) released the updated version of the Guidelines for the Diagnosis and Treatment of Autism Spectrum Disorder (ASD) in Children and Adolescents . The document, developed by a multidisciplinary working group coordinated by Maria Luisa Scattoni and Primiano Iannone , constitutes an essential reference for clinical practice and the organization of